Distribution of Acanthamoeba Genotypes in Iran: A Systematic Review and Meta-analysis

Main Article Content

Mousa Motavallihaghi
Manoochehr Karami
Khadijeh Rahmati
Pegah Ameri
Fariborz Etemadifar
Amir Hossein Maghsood

Abstract

Introduction: Despite many studies that have been done in different parts of Iran, comprehensive information on the epidemiology of Acanthamoeba is not available. Therefore, this review was conducted to collect the reports from studies accompanied in different parts of the country as a systematic study.

Materials and Methods: Cross-sectional studies that surveyed the prevalence and genotype of Acanthamoba in Iran were included. The quality of the included studies was evaluated using STROBE checklist. Heterogeneity of the studies was explored using a Chi-squared test at the 5% significance level. Publication bias was assessed using Begg's and Egger's tests. Stata software version 11 was employed for data analysis. Results were reported using a random effect model with 95% CI.

Results: Out of 2234 articles and 715 abstracts of conferences, finally, 42 articles were selected. Six studies were conducted between 2000-2010 years and 36 studies were conducted between 2011 until 2017. The prevalence rate of Acanthamoeba was 39% from 2000 to 2010 and reached 43% during 2011-2017. Also, the prevalence of contamination in human specimens was 24% and in environmental samples was 45% and 48% in water samples. Reported genotypes of Acanthamoeba in Iran include T2, T3, T4,T5,T11,T13and T15 which the most common genotype of Acanthamoeba was T4.

Conclusion: The results of this review showed that the prevalence of Acanthamoeba was not only high in various regions of Iran, but also has been increased in various environmental sources in recent years.

Keywords:
Prevalence, genotype, Acanthamoeba, review, Iran.

Article Details

How to Cite
Motavallihaghi, M., Karami, M., Rahmati, K., Ameri, P., Etemadifar, F., & Maghsood, A. H. (2020). Distribution of Acanthamoeba Genotypes in Iran: A Systematic Review and Meta-analysis. South Asian Journal of Parasitology, 3(4), 1-10. Retrieved from http://journalsajp.com/index.php/SAJP/article/view/30101
Section
Systematic Review Article

References

Rahdar M, Niyyati M, Salehi M, Feghhi M, Makvandi M, Pourmehdi M, et al. Isolation and genotyping of acanthamoeba strains from environmental sources in Ahvaz City, Khuzestan Province, Southern Iran. Iranian journal of parasitology. 2012;7(4):22.

Maghsood AH, Sissons J, Rezaian M, Nolder D, Warhurst D, Khan NA. Acanthamoeba genotype T4 from the UK and Iran and isolation of the T2 genotype from clinical isolates. Journal of medical microbiology. 2005;54(8):755-9.

Niyyati M, Lasjerdi Z, Nazar M, Haghighi A, Mojarad EN. Screening of recreational areas of rivers for potentially pathogenic free-living amoebae in the suburbs of Tehran, Iran. Journal of Water and Health. 2012;10(1):140-6.

Behniafar H, Niyyati M, Lasjerdi Z. Molecular characterization of pathogenic Acanthamoeba isolated from drinking and recreational water in East Azerbaijan, Northwest Iran. Environmental Health Insights. 2015;9:7.

Motavalli M, Khodadadi I, Fallah M, Maghsood AH. Effect of oxidative stress on vital indicators of Acanthamoeba castellanii (T4 genotype). Parasitology Research. 2018;117(9):2957-62.

Soosaraei M, Haghi M, Etemadifar F, Fakhar M, Teshnizi S, Hezarjaribi H, et al. editors. Status of theileriosis among herbivores in Iran: A systematic review and meta-analysis. Veterinary World. 2018; 11(3):332-341.

Gallo V, Egger M, McCormack V, Farmer PB, Ioannidis JP, Kirsch-Volders M, et al. STrengthening the reporting of observational studies in epidemiology: Molecular epidemiology strobe-me. An extension of the STROBE statement. J Epidemiol Community Health. 2012; 66(9):844-54.

Vandenbroucke JP, Von Elm E, Altman DG, Gøtzsche PC, Mulrow CD, Pocock SJ, et al. Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): Explanation and elaboration. International Journal of Surgery. 2014; 12(12):1500-24.

Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ: British Medical Journal. 2003;327(7414):557.

Rücker G, Schwarzer G, Carpenter JR, Schumacher M. Undue reliance on I 2 in assessing heterogeneity may mislead. BMC Medical Research Methodology. 2008;8(1):79.

Haghi MM, Etemadifar F, Fakhar M, Teshnizi SH, Soosaraei M, Shokri A, et al. Status of babesiosis among domestic herbivores in Iran: A systematic review and meta-analysis. Parasitology Research. 2017;116(4):1101-9.

Leandro G. Meta-analysis in Medical Research: The handbook for the understanding and practice of meta-analysis: John Wiley & Sons; 2008.

Egger M, Smith GD, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997; 315(7109):629-34.

Eftekhar M, Nazem Ame, Haghighi A, Sharifi K, Nouchi Z, Athari A. Detection of Acanthamoeba from fresh water using polymerase chain reaction. 2009;33(1):39-42.

Niyyati M, Ebrahimi M, Haghighi A, Haydari S. Isolation and genotyping of Acanthamoeba spp. from recreational soil of parks in Tehran, Iran. Armaghane Danesh. 2013;18(7):530-8.

Gg S, Solhjoo K, Rohi R, Zia-Jahromi S. Isolation and identification of free living amoeba (Naegleria and Acanthamoeba) in Shiraz water resources by morphological criteria. Journal of Jahrom University of Medical Sciences. 2012;10(3):27.

Mosayebi M, Ghorbanzadeh B, Eslamirad Z, Ejtehadifar M, Rastad B. The isolation and detection of acanthamoeba in rural water sources of Arak, Iran. Medical Laboratory Journal. 2014;7(4):66-71.

Salehi M. Acanthamoeba strains genotypes prevalence in water sources in Bojnurd City. Journal of Birjand University of Medical Sciences. 2014;21(2):260-6.

Latifi A, Niyyati M, Valayi N, Lasjerdi Z. Frequency survey of free-living amoebae isolated from improved hot springs of Mazandaran Province, 2014. Research in Medicine. 2015;38(4):214-20.

Khoushzaban F, Deylamiasl A, Gabarvand M, Hashemian S, Rezaeian M. Diagnosis of Acanthamoeba keratitis by Polymerase Chain Reaction. 2004;17(1):30-36.

Rezaeian M, Niyyati M, Farnia S, Haghi AM. Isolation of Acanthamoeba spp. from different environmental sources. Iranian Journal of Parasitology. 2008;3(1):44-7.

Niyyati M, Lorenzo-Morales J, Rahimi F, Motevalli-Haghi A, Martín-Navarro CM, Farnia S, et al. Isolation and genotyping of potentially pathogenic Acanthamoeba strains from dust sources in Iran. Transactions of the Royal Society of Tropical Medicine and Hygiene. 2009; 103(4):425-7.

Bagheri H, Shafiei R, Shafiei F, Sajjadi S. Isolation of acanthamoeba spp. From drinking waters in several hospitals of iran. Iranian Journal of Parasitology. 2010; 5(2):19.

Lasjerdi Z, Niyyati M, Haghighi A, Shahabi S, Biderouni FT, Taghipour N, et al. Potentially pathogenic free-living amoebae isolated from hospital wards with immunodeficient patients in Tehran, Iran. Parasitology Research. 2011;109(3):575-80.

Mahmoudi MR, Taghipour N, Eftekhar M, Haghighi A, Karanis P. Isolation of Acanthamoeba species in surface waters of Gilan province-north of Iran. Parasitology Research. 2012;110(1):473- 7.

Nazar M, Haghighi A, Niyyati M, Eftekhar M, Tahvildar-Biderouni F, Taghipour N, et al. Genotyping of Acanthamoeba isolated from water in recreational areas of Tehran, Iran. Journal of Water and Health. 2011;9(3):603-8.

Badirzadeh A, Niyyati M, Babaei Z, Amini H, Badirzadeh H, Rezaeian M. Isolation of free-living amoebae from sarein hot springs in ardebil province, Iran. Iranian Journal of Parasitology. 2011;6(2):1.

Mohammadi-Ghalehbin B, Hatam GR, Mohammad-Pour I, Ghobakhloo N, Foroughi-Parvar F. Recognition of pathogenic free-living amoebae in the surface water in Shiraz, Iran. Journal of Health Sciences and Surveillance System. 2014;2(4):164-7.

Niyyati M, Rahimi F, Lasejerdi Z, Rezaeian M. Potentially pathogenic free-living amoebae in contact lenses of the asymptomatic contact lens wearers. Iranian Journal of Parasitology. 2014; 9(1):14.

Memari F, Niyyati M, Haghighi A, Seyyed Tabaei S, Lasjerdi Z. Occurrence of pathogenic Acanthamoeba genotypes in nasal swabs of cancer patients in Iran. Parasitology Research. 2015;114(5).

Mahmoudi M, Rahmati B, Seyedpour S, Karanis P. Occurrence and molecular characterization of free-living amoeba species (Acanthamoeba, Hartmannella, and Saccamoeba limax) in various surface water resources of Iran. Parasitology Research. 2015;114(12).

Mahmoudi MR, Kazemi B, Haghighi A, Karanis P. Detection of Acanthamoeba and toxoplasma in river water samples by molecular methods in Iran. Iranian Journal of Parasitology. 2015;10(2):250.

Behniafar H, Niyyati M, Lasjerdi Z, Dodangeh S. High occurrence of potentially pathogenic free living amoebae in water bodies of kaleybar and khodaafarin, east azerbaijan province. Current World Environment. 2015;10(Special Issue 1 (2015)):727-31.

Niyyati M, Mahyar M, Haghighi A, Vala MH. Occurrence of potentially pathogenic bacterial-endosymbionts in Acanthamoeba Spp. Iranian Journal of Parasitology. 2015;10(2):181.

Niyyati M, Nazar M, Haghighi A, Nazemalhosseini E. Reporting of T4 genotype of Acanthamoeba isolates in recreational water sources of gilan province, northern Iran. Novelty in Biomedicine. 2015;3(1):20-4.

Lasjerdi Z, Niyyati M, Lorenzo-Morales J, Haghighi A, Taghipour N. Ophthalmology hospital wards contamination to pathogenic free living Amoebae in Iran. Acta Parasitologica. 2015;60(3):417-22.

Ghadar GJS, Solhjoo K, Norouz NM, Rohi R, Zia JS. Isolation and identification of free living amoeba (Naegleria and Acanthamoeba) in Shiraz water resources by morphological criteria; 2012.

Ebrahimi M, Niyyati M, Haghighi A, Haydari S. Isolation and genotyping of Acanthamoeba spp. from recreational soil of parks in Tehran, Iran. Armaghane-danesh. 2013;4:530-8.

Solgi R, Niyyati M, Haghighi A, Taghipour N, Tabaei SJS, Eftekhar M, et al. Thermotolerant Acanthamoeba spp. isolated from therapeutic hot springs in Northwestern Iran. Journal of Water and Health. 2012;10(4):650-6.

Hooshyar H, Hosseinbigi B, Saraei M, Alizadeh S, Eftakhar M, Rasti S, et al. Genotyping of Acanthamoeba isolated from surface and stagnant waters of Qazvin, Central Iran. Iranian Red Crescent Medical Journal. 2013;15(6):536.

Armand B, Motazedian M, Asgari Q. Isolation and identification of pathogenic free-living amoeba from surface and tap water of Shiraz City using morphological and molecular methods. Parasitology Research. 2016;115(1):63-8.

Mahmoudi MR, Berenji F, Fata A, Najafzadeh MJ, Asadian A, Salehi M. Morphological characterization of potentially pathogenic thermophilic amoebae isolated from surface water in Mashhad, Iran. Jundishapur Journal of Microbiology. 2015;8(4).

Manesh RM, Niyyati M, Yousefi HA, Eskandarian AA. Isolation of Acanthamoeba spp. from different water sources in Isfahan, central Iran, 2014. Journal of Parasitic Diseases. 2016; 40(4):1483-6.

Aghajani A, Dabirzadeh M, Maroufi Y, Hooshyar H. Identification of Acanthamoeba genotypes in pools and stagnant water in ponds in Sistan Region in Southeast Iran. Turkiye Parazitol Derg. 2016;40:132-6.

Niyyati M, Saberi R, Latifi A, Lasjerdi Z. Distribution of Acanthamoeba genotypes isolated from recreational and therapeutic geothermal water sources in Southwestern Iran. Environmental Health Insights. 2016;10:69.

Rahdar M, Tavalla M, Ebadi S, Salehi M. The identification of free-living amoebae in water and soil from in and around Ahvaz, southwest Iran. Biochemical and Cellular Archives. 2016;16(2):379-82.

Karamati SA, Niyyati M, Lorenzo-Morales J, Lasjerdi Z. Isolation and molecular characterization of Acanthamoeba genotypes isolated from soil sources of public and recreational areas in Iran. Acta Parasitologica. 2016;61(4):784-9.

Khezri A, Fallah E, Mostafazadeh M, Spotin A, Shahbazi A, Mahami-Oskouei M, et al. Molecular and morphometric characterization of Acanthamoeba spp. from different water sources of northwest iran as a neglected focus, co-bordered with the country of Iraq. Jundishapur Journal of Microbiology. 2016;9(11).

Shokri A, Sarvi S, Daryani A, Sharif M. Isolation and genotyping of Acanthamoeba spp. as neglected parasites in North of Iran. The Korean Journal of Parasitology. 2016;54(4):447.

Behravan M, Behniafar H, Einipour S, Dorani N, Naghizadeh A. Morphological and molecular identification of Acanthamoeba Spp from surface waters in Birjand, Iran, During 2014-2015. Archives of Hygiene Sciences. 2016; 5(2):117-22.

Mafi M, Niyyati M, Haghighi A, Lasjerdi Z. Contamination of swimming pools and park ponds with free living amoebae in Tehran. Med J Tabriz Uni Med Sciences Health Services. 2017;38(6):60-7.

Niyyati M, Ebrahimi M, Haghighi A, Haydari S. Isolation and genotyping of Acanthamoeba spp. from recreational soil of parks in Tehran, Iran. Armaghane Danesh Bimonthly Journal. 2013; 18(7):530-8.

Niyyati M, Lasgerdi Z, Lorenzo-Morales J. Detection and molecular characterization of potentially pathogenic free-living amoebae from water sources in Kish Island, Southern Iran. Microbiology insights. 2015;8(Suppl 1):1.

Niyyati M, Lorenzo-Morales J, Rezaie S, Rahimi F, Mohebali M, Maghsood AH, et al. Genotyping of Acanthamoeba isolates from clinical and environmental specimens in Iran. Experimental Parasitology. 2009;121(3):242-5.

Rezaian M, Bagheri F, Farnia S, Babai Z. Isolation of Pathogenic amoeba (naegleria and acanthameoba) from water sourcesand margin soils of reveirs and lakes in kazerun. Journal of School of Public Health and Institute of Public Health Research. 2003;1(3):41-8.