https://journalsajp.com/index.php/SAJP <p style="text-align: justify;"><strong>South Asian Journal of Parasitology</strong>&nbsp;aims to publish high-quality papers (<a href="/index.php/SAJP/general-guideline-for-authors">Click here for Types of paper</a>)&nbsp;all areas of basic and applied parasitology.</p> <p style="text-align: justify;">This is an open-access journal which means that all content is freely available without charge to the user or his/her institution. Users are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. This is in accordance with the BOAI definition of open access.</p> en-US [email protected] (South Asian Journal of Parasitology) [email protected] (South Asian Journal of Parasitology) Wed, 02 Sep 2026 13:06:59 +0000 OJS 3.3.0.21 http://blogs.law.harvard.edu/tech/rss 60 https://journalsajp.com/index.php/SAJP/article/view/308 <p>Sarcoptic mange caused by <em>Sarcoptes scabiei</em> var. <em>canis</em> is a contagious canine dermatosis, and apparent ivermectin treatment failure raises concern about reduced acaricide susceptibility. This study evaluated the clinical response to a three-dose ivermectin protocol and compared <em>in vitro</em> ivermectin susceptibility between mites recovered from clinically refractory dogs and a reference susceptible isolate. Thirty naturally infested dogs received subcutaneous ivermectin at 300 µg/kg on days 0, 14, and 28, with serial skin scrapings and pruritus assessment through day 42. Mites from refractory dogs were pooled as a field-resistant isolate and tested against a susceptible isolate using ivermectin contact bioassays. Twenty-four dogs (80%) became mite-negative with more than 75% pruritus resolution, whereas six dogs (20%) remained mite-positive with less than 25% pruritus reduction and were classified as clinically refractory. At 1% ivermectin, 24-hour mortality was 34% in the field-resistant isolate compared with 91% in the susceptible isolate. The 24-hour LC₅₀ was 0.71% for the field-resistant isolate and 0.09% for the susceptible isolate, corresponding to a resistance ratio of approximately 7.9. LT₅₀ at 1% increased from 2.1 to 9.4 hours. These findings are consistent with a marked phenotypic reduction in ivermectin susceptibility associated with clinical treatment failure and support confirmatory follow-up testing, careful acaricide selection, and continued surveillance.</p> Sirigireddy Sivajothi, Bhavanam Sudhakara Reddy, Dadireddy Narmada Raghavi Copyright (c) 2026 Author(s). The licensee is the journal publisher. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. https://journalsajp.com/index.php/SAJP/article/view/308 Wed, 02 Sep 2026 00:00:00 +0000 https://journalsajp.com/index.php/SAJP/article/view/309 <p>Schistosomiasis is a major public health challenge in irrigation-based communities. The recent establishment of the invasive snail, <em>Pomacea canaliculata</em>, within the Mwea Irrigation Scheme has raised concerns regarding its interaction with native vector snails and its potential influence on schistosomiasis transmission. However, its ecological relationship with native vector snails and the temporal patterns of reported human schistosomiasis following its establishment remain unclear. This study aimed to evaluate ecological and epidemiological evidence for the potential indirect role of <em>P. canaliculata</em> in schistosomiasis transmission by assessing its spatiotemporal distribution and abundance relative to native vector snails and examining temporal trends in reported human schistosomiasis following its establishment. A cross-sectional survey was conducted at 32 sites in irrigation canals and rice paddies during the rainy and dry seasons to assess snail distribution and abundance, while hospital surveillance records for 2019–2025 were analysed for temporal trends. Seasonal and habitat-related differences in snail abundance were assessed using non-parametric tests, while temporal trends in reported human schistosomiasis were evaluated using linear regression and Kendall’s tau correlation. <em>P. canaliculata</em> occurred at all 32 sites, with significantly higher abundance during the rainy season and in irrigation canals (p ≤ 0.05). Native vector snails were absent from 18 (56.2%) sites occupied by <em>P. canaliculata</em> and co-occurred at 14 (43.8%) sites. Reported human schistosomiasis cases declined by 86.7% between 2019 and 2025, with a significant overall temporal decline. The widespread establishment of <em>P. canaliculata</em>, its occurrence where native vector snails were absent, and the concurrent decline in reported human schistosomiasis following its establishment suggest a potential indirect role in transmission through ecological effects on native vector snail populations. However, temporal ecological changes cannot be established from a cross-sectional study. Longitudinal studies are therefore required to determine whether the continued establishment of <em>P. canaliculata</em> results in measurable changes in native vector snail populations and schistosomiasis transmission over time.</p> Hezron Kibet Kemboi, Anne J. G. Michura, Ngugi H. Njenga Copyright (c) 2026 Author(s). The licensee is the journal publisher. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. https://journalsajp.com/index.php/SAJP/article/view/309 Mon, 07 Sep 2026 00:00:00 +0000